Everything shared here is based on my own research and personal experience. While I strive to provide accurate and well-researched information, I am not a doctor. Always conduct your own research, consult with a medical professional if needed, and make informed decisions based on your own circumstances. I may be wrong at times, and I welcome discussion and differing perspectives.
Today is Wednesday, February 19th, and my shipment of enclomiphene has finally arrived. This marks a major turning point in my journey, but it hasn’t been without some unexpected hurdles. In my last post, I shared my concerns about not being able to discuss my preferred dosing strategy with my assigned doctor before my prescription was finalized. Unfortunately, that issue remains unresolved. The enclomiphene I received comes in MOJO 3.5 capsules, which are very small and not in a format that allows for easy splitting. This means my initial plan to take 6.75 mg every other day is no longer an option unless I start opening the capsules and measuring doses manually. Instead, I have to decide whether I will take 25 mg every three days or every other day.
Understanding the Half-Life of Enclomiphene
Enclomiphene is one of two isomers in clomiphene citrate, the other being zuclomiphene. Enclomiphene is the more potent and shorter-acting isomer responsible for increasing luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulates natural testosterone production.
Studies suggest the half-life of enclomiphene ranges from about 10 to 30 hours, with most data converging around 11 to 27 hours. In practical terms:
• At an 11-hour half-life, a 25 mg dose would be at 12.5 mg after about 11 hours, 6.25 mg after 22 hours, and around 3 mg after 33 hours.
• At a 27-hour half-life, a 25 mg dose would be at 12.5 mg after 27 hours, 6.25 mg after 54 hours, and 3 mg after 81 hours.
The variability means that most people clear the drug within three to five days.
Can You Take It Every Three Days?
Taking enclomiphene every three days (Q3D) is a reasonable option because it aligns with the clearance window. Given the estimated half-life, taking 25 mg every three days would still maintain a baseline of enclomiphene in the system while avoiding excessively high levels. The following is an example of the decay curve with every-three-day dosing:
• Day 1: 25 mg
• Day 2: ~12.5 mg remaining
• Day 3: ~6.25 mg remaining
• Day 4: Redose 25 mg → cycle repeats
This results in a rolling average that keeps enclomiphene active but at a lower cumulative level than daily dosing. My doctor recommended every-other-day dosing if I wanted to take a lower amount, but I may still opt for every three days to minimize potential side effects.
Tadalafil Mentioned in the Drug Information Sheet
One of the most unexpected parts of this process came when I reviewed the drug information sheet included with my shipment. The document states that the enclomiphene capsules may contain tadalafil, which was surprising. This raised concerns about whether the capsules contained 25 mg of enclomiphene alone or if the formulation was a combination of enclomiphene and tadalafil.
Tadalafil, commonly known as the active ingredient in Cialis, is a PDE5 inhibitor used to treat erectile dysfunction and benign prostatic hyperplasia (BPH). It works by relaxing blood vessels and increasing blood flow, often resulting in improved endothelial function. Some people take it daily in low doses for cardiovascular benefits, but it is not something I was expecting in an enclomiphene prescription.
I reached out to my assigned doctor for clarification. His response was that this should not be the case, and he advised me to report it to Maximus support immediately. According to him, the pharmacy should not be giving anyone the impression that the medicine contains tadalafil, so for now, I will assume that my prescription contains only enclomiphene.
Adjusting My Plan
Now that I know I cannot split the pills as originally planned, my final decision on dosing will be made tomorrow before I take my first dose. I am leaning toward 25 mg every three days but will continue researching before committing to that schedule.
My doctor also confirmed that testosterone levels fluctuate widely and that diet, sleep, stress, and other factors play a role in day-to-day variations. This aligns with what I already understood but does not fully explain why my total and free testosterone were significantly lower in my most recent lab work. I will continue monitoring my levels and will get follow-up labs four weeks after starting enclomiphene.
Changes to My Training and Diet
I will be adjusting my workout split next week, moving to a push/pull/legs/push/pull routine Monday through Friday. This is a slight shift from my previous plan but keeps the same core principles in place. My diet remains at 1,629 calories per day, prioritizing high protein and low fat, and my trend weight today is 186.3 lbs.
Final Thoughts
This experience with Maximus Tribe has been mostly positive so far, but the lack of initial consultation on dosing has been disappointing. The unexpected mention of tadalafil in the drug information sheet was also concerning, though my doctor reassured me that my prescription should only contain enclomiphene. The biggest decision now is how to structure my dosing to maximize benefits while minimizing side effects.
In the next few weeks, I will closely monitor testosterone levels, gym performance, mood, and potential side effects. I plan to share updates along the way, including any adjustments I make.
Unfortunately, my posts are still being removed from Reddit without explanation. If you want to stay updated on my progress, sign up for email notifications here on the blog. I am working to get this working properly. You can also leave a comment below if you have any insights, questions, or personal experiences with enclomiphene.
