Everything shared here is based on my own research and personal experience. While I strive to provide accurate and well-researched information, I am not a doctor. Always conduct your own research, consult with a medical professional if needed, and make informed decisions based on your own circumstances. I may be wrong at times, and I welcome discussion and differing perspectives.
I’m Tyson Voss—an alias I’ll be using to document this process. While I prefer to remain anonymous, my experience will be fully transparent. My goal is to provide a detailed, research-backed account of my journey with enclomiphene, from initial considerations to long-term results.
In my extensive reading of anecdotal reports, I found that most discussions centered around testosterone levels rising or the potential side effects, but very few addressed the real-world impact—does it translate to strength gains in the gym? Does it improve body composition in a meaningful way? How does it affect motivation, recovery, and overall well-being? These gaps in available information led me to start this blog, documenting not just lab results, but the tangible lifestyle changes that occur when using this compound.
I turned 30 at the end of 2024. I’m 6’0” and currently weigh 187 lbs. Over the past three years, I have dedicated myself to structured training and strict nutritional tracking, maintaining detailed records of my caloric intake and macronutrient distribution. My progress has been achieved entirely naturally—without testosterone replacement therapy (TRT), anabolic steroids, or other performance-enhancing drugs. The only supplements I’ve used consistently are creatine and protein powder, and for a brief period, boron, which I discontinued after noticing a small instance of alopecia areata (could be totally unrelated).
Why I Decided to Start Enclomiphene
My decision to explore enclomiphene did not come impulsively. I have spent months researching its mechanism of action, potential benefits, and associated risks. As someone who has optimized training, nutrition, and recovery, I wanted to ensure I was making an informed decision based on both scientific literature and anecdotal reports from individuals with similar goals.
I had no prior reason to suspect low testosterone. My energy levels, mood, and gym performance were relatively stable, though I noticed a plateau in strength and some mild symptoms typically associated with suboptimal androgen levels—reduced sleep quality, occasional lethargy, and a moderate decline in libido. While these were not severe, they were enough to warrant investigation.
Baseline Bloodwork and Interpretation
January 27th 2025, I had my total testosterone, free testosterone, estradiol, and IGF-1 levels tested before making any decisions. The results were as follows:
• Total Testosterone: 494 ng/dL
• Free Testosterone: 67 pg/mL
• IGF-1: 120 ng/mL
• Estradiol: 27 pg/mL
From a clinical standpoint, these numbers are not considered low. However, they are on the lower end of the mid-range for a physically active 30-year-old male. Most research indicates that testosterone levels decline gradually with age, but lifestyle factors such as nutrition, sleep, body fat percentage, and training intensity can influence hormone production significantly.
Free testosterone, in particular, is a crucial marker, as it represents the bioavailable portion that actively interacts with androgen receptors. While my free testosterone was within range, I believe there is room for optimization, especially considering that enclomiphene specifically targets hypothalamic-pituitary-gonadal (HPG) axis regulation by stimulating endogenous testosterone production without the suppression caused by exogenous testosterone administration.
Why Enclomiphene Over TRT or SARMs?
I evaluated several approaches before arriving at enclomiphene as my preferred option.
Testosterone Replacement Therapy (TRT)
TRT is the most well-documented and effective method for increasing testosterone levels. However, it comes with significant drawbacks, especially for someone in my position. TRT suppresses natural luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production, effectively shutting down endogenous testosterone synthesis. This is particularly problematic for fertility preservation, as long-term TRT use can lead to spermatogenic suppression. Given that I plan to have children in the near future, this alone ruled out TRT as an option.
Selective Androgen Receptor Modulators (SARMs)
SARMs, such as RAD-140, LGD-4033, and MK-677, have gained popularity due to their ability to provide anabolic effects similar to traditional androgens while being marketed as having fewer side effects. However, the long-term safety profile of SARMs remains poorly understood, and many compounds still result in testosterone suppression, requiring post-cycle therapy (PCT) to restore endogenous production.
Why Enclomiphene?
Enclomiphene is the isolated trans-isomer of clomiphene citrate, which functions as a selective estrogen receptor modulator (SERM). Unlike traditional Clomid therapy, enclomiphene is more selective in its action and primarily stimulates LH and FSH secretion without the estrogenic side effects associated with zuclomiphene (the other isomer in Clomid).
• Preserves natural testosterone production rather than replacing it
• Stimulates the hypothalamic-pituitary-gonadal axis, leading to an increase in endogenous testosterone
• Does not shut down fertility, making it a viable option for those who wish to maintain reproductive health
This mechanism made enclomiphene the best choice for my specific goals—to increase testosterone while avoiding permanent suppression or exogenous administration.
Concerns About Risk Management
Despite its advantages, enclomiphene is not without risks. My primary concerns include:
• Increased estrogen levels – Due to the mechanism of action, estradiol may increase, leading to potential issues such as water retention, mood swings, or exacerbation of existing gyno.
• Vision-related side effects – Some anecdotal reports suggest eye floaters or visual disturbances in individuals using SERMs, though this is not well-documented in clinical studies.
• Variable response – Not everyone experiences a significant testosterone boost from enclomiphene, and individual response can be influenced by baseline hormone levels and genetic factors.
I plan to mitigate these risks by starting at a conservative dose of 6.5mg every other day, monitoring bloodwork regularly, and adjusting based on my response. If estrogenic side effects become problematic, I will evaluate whether a dosage adjustment or the introduction of an aromatase inhibitor (AI) is necessary. However, if the side effects outweigh the benefits or if I see no meaningful improvements, I am fully prepared to discontinue enclomiphene altogether.
Training and Lifestyle Adjustments
I currently follow a four-day split focusing on progressive overload:
• Chest/Triceps
• Back/Biceps
• Shoulders/Core
• Legs
I have largely avoided traditional squats and deadlifts due to previous injuries but may incorporate them selectively as a metric for progress. My goal over the next several months is to maintain a lean bulk, eating at a slight caloric surplus, before entering a cutting phase closer to summer.
Additionally, I will be reducing alcohol consumption, as excessive drinking has been shown to negatively impact testosterone and recovery. While I do not plan to eliminate alcohol entirely, I will monitor my intake and its effects on my progress.
Getting Started: Ordering Through Maximus Tribe
I chose Maximus Tribe as my source for enclomiphene due to the convenience of telemedicine-based prescription access. While there are cheaper sources, I opted for a legitimate provider to ensure pharmaceutical-grade quality and physician oversight.
I am currently awaiting confirmation of eligibility through mail-in blood testing, after which I will begin treatment and document my experience in detail.
Tracking Progress and Next Steps
I will be tracking strength metrics, body composition, and subjective well-being to determine enclomiphene’s effectiveness. In addition to bi-monthly bloodwork, I may incorporate DEXA scans to analyze body composition changes.
Moving forward, this blog will serve as a comprehensive diary of my enclomiphene experience, covering both physiological and performance-based outcomes.
For those interested in following along, I will be providing regular updates, including detailed lab results, training progress, and any side effects encountered throughout the process.
Let’s see where this goes.
Regarding AIs, natural options for those considering are Boron, DIM and CDG. DIM helps estrogen metabolism but is also purported to lower androgens.
I’ve had success with the former two, in lowering general E2 sides and eye related side effects supposedly caused by E2.
Keen to hear about anyone who has used CDG or traditional AIs like Arimidex etc